Tyrosinase Inhibitors and Sesquiterpene Diglycosides from Guioa villosa

Abstract

Through a bioassay-guided phytochemical investigation involving mushroom tyrosinase inhibitory activity, seven farnesyl diglycosides (1 - 7), five flavonoids (8 - 12), one trimeric proanthocyanidin (13), two triterpenes (14 and 15), and one cerebroside (16), were isolated from the leaves of Caledonian Guioa villosa. Among them, crenulatosides E, F and G (1 - 3) were new acyclic sesquiterpene diglycosides. The sesquiterpene diglycosides isolated from the active EtOAc extract showed no inhibitory activity, whereas betulin (14), lupeol (15) and soyacerebroside I (16) demonstrated a potent tyrosinase inhibitory activity.

Guioa villosa - Sapindaceae - terpenoids - tyrosinase inhibitor

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